Search results for "Natural course"
showing 10 items of 15 documents
Probiotics Can Cure Oral Aphthous-Like Ulcers in Inflammatory Bowel Disease Patients: A Review of the Literature and a Working Hypothesis
2019
Dysbiosis has been associated with the onset of several chronic autoimmune or inflammatory pathologies (e.g., inflammatory bowel diseases—IBD), because of its primary role in the establishment of a chronic inflammatory process leading to tissue damage. Inflammatory bowel diseases can even involve areas far away from the gut, such as the extraintestinal manifestations involving the oral cavity with the onset of aphthous-like ulcers (ALU). Studies carried out on animal models have shown that intestinal dysbiosis may be related to the development of autoimmune diseases, even if the mechanisms involved are not yet well known. The aim of this paper is to verify the hypothesis that in inflammator…
Clinical activity after fingolimod cessation: Disease reactivation or rebound?
2018
Background and purpose There is debate as to whether the apparent rebound after fingolimod discontinuation is related to the discontinuation itself or whether it is due to the natural course of highly active multiple sclerosis (MS). Our aim was to survey the prevalence of severe reactivation and rebound after discontinuation of fingolimod in a cohort of Italian patients with MS. Methods Patients with relapsing-remitting MS who were treated with fingolimod for at least 6 months and who stopped treatment for reasons that were unrelated to inefficacy were included in the analysis. Results A total of 100 patients who had discontinued fingolimod were included in the study. Fourteen patients (14%…
Amyotrophic lateral sclerosis in Palermo, Italy: an epidemiological study
1989
The incidence, prevalence and natural course of ALS were determined in the population of the province of Palermo, Italy. The average annual incidence calculated for the years 1973 through 1984, was 044./100.000 inhabitants. The prevalence rate on prevalence day December 31, 1984, was 1.67/100.000 population. The male/female ratio was 1.38. The mean age at onset was 54.3±11.02. The most common clinical form was the conventional one (61.4%); the bulbar form was more frequent among females than males. The mean duration of the disease was 33.7±35.8 months. The longest duration belongs to the pseudopolyneuritic form. The median survival was 36 months: 16 months for the bulbar, 36 months for the …
Current Concepts and Perspectives on Brain Arteriovenous Malformations: A Review of Pathogenesis and Multidisciplinary Treatment.
2021
Brain arteriovenous malformations (bAVMs) are unusual vascular pathologies characterized by the abnormal aggregation of dilated arteries and veins in the brain parenchyma and for which the absence of a normal vascular structure and capillary bed leads to direct connections between arteries and veins. Although bAVMs have long been believed to be congenital anomalies that develop during the prenatal period, current studies show that inflammation is associated with AVM genesis, growth, and rupture. Interventional treatment options include microsurgery, stereotactic radiosurgery, and endovascular embolization, and management often comprises a multidisciplinary combination of these modalities. T…
Definite and indeterminate nonalcoholic steatohepatitis share similar clinical features and prognosis : A longitudinal study of 1893 biopsy-proven no…
2021
[Background and Aim] Histological score systems may not fully capture the essential nonalcoholic steatohepatitis (NASH) features, which is one of the leading causes of screening failure in clinical trials. We assessed the NASH distribution and its components across the fibrosis stages and their impact on the prognosis and their relationship with the concept of metabolic-associated fatty liver disease (MAFLD).
One‐quarter of chronic hepatitis D patients reach HDV‐RNA decline or undetectability during the natural course of the disease
2021
BACKGROUND Spontaneous HDV-RNA fluctuations, assessed by nonstandardised in-house assays, have been reported during the course of chronic hepatitis delta (CHD). AIMS To evaluate changes in serum HDV-RNA concentrations in untreated CHD patients and correlate these changes with other HBV markers. METHODS A total of 323 consecutive serum samples from 56 CHD patients (detectable HDV-RNA) followed for >3 years were retested for HDV-RNA levels by a sensitive technique using the first WHO international HDV-RNA standard. Quantitative HBsAg, HBV-DNA, and HBV-RNA were also determined. RESULTS Most participants were male, middle-aged, white European, and HBeAg-negative (82%). Almost half had liver cir…
Progress of instability in fragility fractures of the pelvis: An observational study.
2019
Abstract Fragility fractures of the pelvis (FFP) are an increasing entity among elderly persons. Characteristics are different from high-energy pelvic trauma. Little is known about the natural course of FFP in conservative and after operative treatment. Materials and methods Medical charts and radiologic data of 148 patients with an FFP, who were admitted in a 3-year period, were analysed retrospectively. Incidence and characteristics of fracture progression (FP) were noted. Results Patients presenting early after a traumatic event had more often non-displaced fractures, fractures with lower FFP Type classification and were more frequently treated conservatively. FP was observed in 21 cases…
In Vivo Observations on Tumor Invasion
1989
Tumor invasion in vivo is a very complex and dynamic process which depends upon a variety of interactions between heterogeneous tumor cell populations and the different cellular and extracellular components of the host tissue. This situation cannot be reproduced even in the most sophisticated in vitro system. On the other hand, there is at present no method available for a direct and dynamic observation of tumor invasion deep in the nontransparent living tissue, so that all evidence has to be derived from indirect observations made on the basis of static morphology. But all these limitations do not deny the potential value of in vivo investigations in following the natural course of tumor i…
Atypical Facial Pain
2003
Publisher Summary This chapter discusses “atypical facial pain,” which was introduced originally to distinguish trigeminal neuralgia from other facial pain syndromes. The term “atypical facial pain” is also used mostly as a residual category for otherwise unclassifiable pain syndromes in the facial region. The International Headache Society defines atypical facial pain as a persistent facial pain that does not have the characteristics of the cranial neuralgias and is not associated with physical signs or demonstrable organic causes. It is present daily and persists for most or all of the day. It is confined at onset to a limited area on one side of the face and may spread to the upper and l…
DNA Histogram of Invasive Bladder Carcinoma: Comparison of Flow Cytometry and Automated Image Analysis
1989
Invasive bladder carcinoma is characterized by a considerable interindividual heterogeneity. The natural course of the disease as well as sensitivity of the tumors to various treatment modalities are thus unpredictable. Searching for more accurate characteristics of tumor biology than those presently available, the DNA histograms of 65 paraffin-preserved bladder carcinomas from cystectomy specimens were analyzed. Flow cytometry and automated image analysis, two competing methods, were compared.